Ankur Singh is an Assistant Professor in the Sibley School of Mechanical & Aerospace Engineering at Cornell University. Dr. Singh has strong expertise in the engineering of biomaterials-based platforms for cell and immune modulation, cell-biomaterial interactions, cell adhesion, stem cell engineering, and vaccines. He received his postdoctoral training at Georgia Tech where he employed engineering and molecular cell biology principles to understand human stem cell reprogramming and differentiation, stem and mature cell adhesion, force response and mechanotransduction. Dr. Singh received his Ph.D. in Biomedical Engineering at The University of Texas at Austin. His research has established multi-modal, biomaterials-based functionalized hydrogel and microparticle to enhance the potency of Non-Hodgkin's Lymphoma and Hepatitis vaccines.
Dr. Singh's "Immunotherapy and Cell Engineering Lab (ICEL)" focuses on engineering immune and therapeutic cells by integrating innovative materials and core concepts of cell immunology, biomechanics, and force transmission. The overall goal of ICEL is to understand the fundamentals of cell-material interactions, underlying cell mechanics, signaling, and to establish novel micro-nano-bioengineering strategies to generate therapeutic cells and engineered tissues. We will achieve this by working at the interface of biomaterials, microfluidics and microfabrication, immune cells, stem cells, and mechanotransduction, Specific research focus includes:
1. Immune-engineering: Materials and Molecular Engineering for Modulating Immunity
2. Engineering Human Stem Cells
3. Micro-Nano-Bioengineering for Cell-Matrix Interactions and understanding cell adhesion
Biofluid Mechanics -MAE 6690
- 2016. "Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production." Nature Protocols 12 (1): 168-182. .
- 2016. "Biomaterials-based Ex Vivo Engineered Immune Organoids for Controlled Differentiation of B Cells." Paper presented at BMES 2016 Annual Meeting in Minneapolis, Minnesota, October (4th Quarter/Autumn). .
- 2016. "Pro-Survival Integrin Signaling and Tissue Stiffness in Engineered Tumor Microenvironment Regulate B Cell Receptor Activity in Aggressive Human B Cell Lymphomas." Paper presented at BMES 2016 Annual Meeting in Minneapolis, Minnesota, October (4th Quarter/Autumn). .
- 2016. "Role of Lymphatic-Mimicking Small-Scale Fluid Shear Stress on Survival, Integrin Signaling, and Drug Response in Aggressive Human Lymphoid Tumors." Paper presented at BMES 2016 Annual Meeting in Minneapolis, Minnesota, October (4th Quarter/Autumn). .
- 2016. "Osteoarthritis: Pathology, Mouse Models, and Nanoparticle Injectable Systems for Targeted Treatment." Annals of Biomedical Engineering 44 (6): 2062-2075. .
Selected Awards and Honors
- 2017 Young Investigator Award from the Society for Biomaterials (Society for Biomaterials) 2017
- Keynote Speaker (McMaster University's 3rd Annual Perey Symposium) 2016
- 2015 Biomaterials Outstanding Paper Award (Biomaterials Today) 2016
- Highlighted in Discover Magazine ("100 Top Stories of 2015") 2016
- National Science Foundation CAREER Award (Division of Materials Research, Biomaterials) 2016
- M.Tech (Biomedical Engineering), Indian Institute of Technology-Bombay, 2006
- Ph D (Biomedical Engineering), The University of Texas at Austin, 2010
- Post Doc (Mechanical Engineering (Cell Mechanics)), Georgia Institute of Technology, 2013