Ankur Singh is an Assistant Professor in the Sibley School of Mechanical & Aerospace Engineering at Cornell University. Dr. Singh has strong expertise in the engineering of biomaterials-based platforms for cell and immune modulation, cell-biomaterial interactions, cell adhesion, stem cell engineering, and vaccines. He received his postdoctoral training at Georgia Tech where he employed engineering and molecular cell biology principles to understand human stem cell reprogramming and differentiation, stem and mature cell adhesion, force response and mechanotransduction. Dr. Singh received his Ph.D. in Biomedical Engineering at The University of Texas at Austin. His research has established multi-modal, biomaterials-based functionalized hydrogel and microparticle to enhance the potency of Non-Hodgkin's Lymphoma and Hepatitis vaccines.
Dr. Singh's "Immunotherapy and Cell Engineering Lab (ICEL)" focuses on engineering immune and therapeutic cells by integrating innovative materials and core concepts of cell immunology, biomechanics, and force transmission. The overall goal of ICEL is to understand the fundamentals of cell-material interactions, underlying cell mechanics, signaling, and to establish novel micro-nano-bioengineering strategies to generate therapeutic cells and engineered tissues. We will achieve this by working at the interface of biomaterials, microfluidics and microfabrication, immune cells, stem cells, and mechanotransduction, Specific research focus includes:
1. Immune-engineering: Materials and Molecular Engineering for Modulating Immunity
2. Engineering Human Stem Cells
3. Micro-Nano-Bioengineering for Cell-Matrix Interactions and understanding cell adhesion
Biofluid Mechanics -MAE 6690
- 2013. "Adhesion strength-based, label-free isolation of human pluripotent stem cells." Nature Methods 10 (5): 438-444. .
- 2013. "How vinculin regulates force transmission." Proc Natl Acad Sci USA 110 (24): 9788-9793. .
- 2012. "Nanopatterning Reveals an ECM Area Threshold for Focal Adhesion Assembly and Force Transmission That Is Regulated by Integrin Activation and Cytoskeleton Tension." Journal of Cell Science 125: 5110-5123. Journal Cover Article. .
- 2011. "An Injectable Synthetic Immune-priming Center Mediates Efficient T-cell Class Switching and T-helper 1 Response Against B Cell Lymphoma." Journal of Controlled Release 55: 184-192. Journal Cover Article. .
- 2010. "Efficient Modulation of T Cell Response by Dual-mode, Single Carrier Delivery of Cytokine-targeted siRNA and DNA Vaccine to antigen Presenting Cells." Molecular Therapy 16: 2011-2021. .
Selected Awards and Honors
- Rising Star Award (2014 Biomedical Engineering Society Cellular and Molecular Engineering (BMES-CMBE))
- Travel Grant Award - 17th Annual Hilton Head Workshop, Hilton Head, SC 2013
- International Conference on Stem Cell Engineering Travel Grant Award (Society for Biological Engineering - Seattle, WA) 2012
- Biomedical Engineering Society (BMES) Outstanding Graduate Research Award (Biomedical Engineering Society) 2009
- STAR Award (Society for Biomaterials) 2008
- M.Tech (Biomedical Engineering), Indian Institute of Technology-Bombay, 2006
- Ph D (Biomedical Engineering), The University of Texas at Austin, 2010