Skip to main content



Singh Research Group

Welcome to the Immunotherapy and Cell Engineering Laboratory (ICEL).

Web1

Our research effort centers on creating functional "living" tissues to communicate dynamically with the cell to study and manipulate the cell’s behavior. We apply engineering principles such as biomaterials engineering, fluid mechanics, tissue and material mechanics, cell engineering, and integrate with fundamental concepts of immunology and pathology. Our primary focus is towards creating immune organs/tissues; modulating the behavior of immune cells and their cancers (lymphomas); developing new cure for cancer, infection, and inflammation; as well as understanding mechanics of human stem cells. Our laboratory has developed modular, biomaterials-based organoid technologies that represent 3D immune tissues (e.g. lymph nodes) to study development of healthy and malignant immune cells (lymphomas) in their physio-chemical and mechanical microenvironment, and quantitatively determine predictive power of emerging therapeutics. In addition, we are interested in the engineering of micro-nano-scale technologies for safer, minimally toxic, cancer immunotherapy. We have three major directions: 

  • Immuno-engineering: Develop materials for creating ex vivo immune organs, modulate immunity against lymphoma cancer, infections, and inflammation. 
  • Stem Cell Engineering:  Study interactions of stem cells within their local surroundings, which could lead to new advances in regenerative medicine, including the grafting of neurons for short or long nerve gaps in the treatment of neurological disorders. 
  • Cell Mechanobiology and Micro-Nano-Bioengineering: Study interactions of cells with their extracellular matrix (such as adhesive integrins and focal adhesions) and develop engineered micro-nano-technologies, nanomaterials, and tissue surrogates  
Recent News

4/07/2017 Prof Singh receives the prestigious Society for Biomaterials Young Investigator Award! Gives a plenary lecture at the 2017 SFB Annual Meeting in Minneapolis!

SFB1 SFBA
SFB 3

3/22/2017 Big day in Singh lab!! We are very excited to receive a new ~$1.2 Million funding from the National Cancer Institute of the National Institutes of Health (NIH) to engineer a "Lymphoma-on-Chip" technology, called LETSSGo. LETSSGo will improve our understanding of genetically diverse and highly resistant cancers of the immune system. Thank you for your support NIH/NCI. 

See Cornell Research:

NCI IMAT

02/10/2017 ACS paper figure became a part of the cover!
ACS
02/01/2017 Congrats Apoorva on the acceptance of his research article on the role of lymph node tissue stiffness on lymphomas!! This article, accepted for publication in JBMR-A, is the first study to show tymph node stiffness modulates surface protein expression in Diffuse Large B Cell Lymphoma in a molecular subtype dependent manner.  

02/01/2017 Congrats Shiv Shah on the acceptance of his review paper on "Cellular Self-assembly and Biomaterials-based Organoid Models of Development and Diseases" in Acta Bio!

 
01/05/2017 Congrats PhD students Alberto on his Nature Protocols paper! 

Purwada and Singh, Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production, Nature Protocols, 2017, 12, 168–182. 

NatP Immune


12/20/2016 Chronicle

12/13/2016 Congrats PhD students Alberto & Shiv! - Their manuscript on "Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex vivo B Cell Activation" was accepted for publication by ACS Biomater. Sci. Eng. 

BMATSC
 

11/24/16 Prof. Ankur Singh has been selected to receive the prestigious 2017 Young Investigator Award from the Society For Biomaterials. This award is specifically given “to recognize an individual who has demonstrated outstanding achievements in the field of biomaterials research within ten years following his/her terminal degree or formal training.” Prof. Singh will receive the award at the 2017 Society For Biomaterials Annual Meeting in Minneapolis, MN (April 5 – 8, 2017).

October'16 Singh lab expands to 9 PhD students! Lab welcomes 4 new PhD students this year!! Kristine Lai (CornellMAE),  Regan Stephenson (CornellBME), Sungwoong Kim (CornellMSE), and Tibra Wheeler (CornellBME)

October'16 Congrats to PhD student Shiv Shah who wine the SASE Rising start award!

October'16 Katrina Lastra and Tina Jing receive the Engineering Learning Initiative Research grants

October'16 Liz Abeles named a Hunter R. Rawlings III Cornell Presidential Research Scholar this year.

06/15/2016 Lab welcomes new PhD student Jessica Elmore! Jessica, a recipient of prestigious Cornell Sloan Fellowship, is co-advised by leading immunologist & our collaborator Prof. Avery August (Chair of Immunology). She will be working in infection and immunity area. Cheers!

06/15/2016 Congrats Singh lab's Shiv Shah who has been selected for a 2016 Graduate Assistantships in Areas of National Need (GAANN) fellowship. The fellowship is awarded as a training grant to Cornell's Meining Schoool of Biomedical Engineering from the US Department of Education. Cheers!

05/18/2016 Prof. Singh received the 2015 Biomaterials Outstanding Paper award from Prof. Kam Leong (Editor-in-Chief of the Biomaterials Journal) at the 10th World Biomaterials Congress in Montreal this past week! The award is in recognition for the development of a B cell follicle organoid which recapitulates the anatomical microenvironment of a lymphoid tissue and thus facilitates the mechanistic understanding of the immune system and has the potential to serve as a model for immunotherapeutic studies. 

Biomaterials Award




03/29/2016 Congrats Shiv Shah and Kathleen Rohrbach
on his Honorable Mention recognition for the NSFGRFP fellowship!

03/21/2016 Congratulations to Singh lab. Their seed grant proposals have been selected for funding by the Cornell Stem Cell Program. Thank you CSCP!

03/21/2016 BME PhD student Shiv Shah joins Singh lab! Shiv is a recipient of prestigious Presidential Life Sciences Fellowship.

03/08/2016 Congratulations to Alberto Purwada, Ye Tian, and our collaborator Avery August on the acceptance of our manuscript to Advanced Healthcare Materials!
#SaferImmunotherapy

01/02/2016 Prof. Singh receives a National Science Foundation (NSF) CAREER award to build dynamic living hydrogels! Cheers! See featured article @ Cornell Research

01/01/2016 Lab's research on immune organs makes top 100 stories of 2015’s “The Year in Science” issue of Discover Magazine! Check out #63.

01/01/2016 Matt Mosquera joins Singh Lab as a new Mechanical Engineering PhD student! 

11/30/2015 Prof Singh is the Co-I on a new translational research program grant awarded by the Leukemia and Lymphoma Society. Project is on “Targeting signaling-mediated transcription in T-cell lymphoma.” Project PI is our long standing collaborator, Dr. Leandro Cerchietti at Weill Cornell Medical College. Congrats to the lymphoma team!

11/20/2015 Apoorva and Alberto pass their A-exams! Great start to the holiday season!

09/11/2015 Singh lab welcomes new members 
Kathleen Rohrbach (PhD student, MSE, Dean's Excellence Fellow); Akanksha Kapoor (M.Eng, BME); Evelyn Haynes (Undergraduate Researcher, MAE, working in collaboration with Cephea Valve Technologies)

07/31/2015 Singh lab moved into the new Kimball Hall facility!
Kimball Hall

06/25/2015 Profs. Singh and Kirby
in Mechanical Engineering awarded the prestigious National Science Foundation (NSF) grant to study "Stem Cell Differentiation and Teratoma-forming Potential in hiPSC-derived Neural Cultures". Thank you NSF for supporting our research!
 
06/10/2015  Singh Lab's "immune organoids" covered in Cornell Chronicle, Science Daily, and widely across many other media outlets

"Engineers' synthetic immune organ produces antibodies" - Cornell Chronicle 
"First functional, synthetic immune organ with controllable antibodies" - Science Daily
"Immune Organ Ex Machina a Germinal Prodigy" - GEN
"'ORGANOID' MAKES ANTIBODIES WITHOUT A BODY" - Futurity 

06/01/2015
Ph.D. student Alberto Purwada engineers biomaterials-based immune organ! Research published in "Biomaterials" - "Ex Vivo Engineered Immune Organoids for Accelerated Germinal Center Reactions". Congrats!! 

06/2015 μSHEAR™- Stem cell technology developed by Prof. Singh at Georgia Tech is licensed. Read more. 

03/2015 Prof. Singh re-elected as the Chair of Immune-engineering SIG (2015-2017) at the Society for Biomaterials.

01/2015 Postdoc Field Tian creates living tumors: Study published in "Blood" - Integrin αVβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells. 

12/ 2014 
Prof. Singh's collaborative work on "Stimuli responsive, light-triggered Materials" published in Nature Materials. 
NM_Singh

    
11/2014 Undergraduate researcher Rebecca Schnieder and our story on "Breaking The Rules to Engineer Human Immune System" featured on Cornell Engineering webpage! 

10/2014 Our arthritis inflammation research is the "Frontispiece" cover of Advanced Healthcare Materials.  Article

09/2014 Singh lab undergraduate researcher Rebecca Schneider awarded the Fall 2014 Engineering Learning Initiatives research award. Congrats!

09/2014 Singh invited by the National Cancer Institute of the NIH to present current lymphoma research at the NCI Division of Cancer Biology Strategic Workshop "Prospective Outlook of Mechanics in Oncology", Rockville, MD (Sep 11-12. 2014)

08/2014 Singh publishes in Advanced Materials with the National Academy of Engineering member and biomaterials pioneer Prof. Nicholas Peppas! 


08/2014  Cornell Profs. Singh and Lammerding featured on the cover of the Cellular and Molecular Bioengineering (CMBE) Journal as one of the inaugural class of CMBE Young Innovators (2014). Congrats to all YIs! 

08/2014 Prof. Singh to give 3 invited talks at the 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'14) to be held from August 26-30, 2014 in Chicago! Link

08/2014 Congratulations Alberto for receiving the prestigious Howard Hughes Medical Institute (HHMI) Med into Grad Scholars Fellowship! We will be studying Multiple Myeloma with our clinical collaborator Dr. Giorgio Inghirami (Weill Cornell Medical College).

07/2014 Spotlights:  Cornell Engineering’s Ankur Singh is among 13 outstanding U.S. scientists recently recognized as 2014 Young Innovators in Cellular and Molecular Bioengineering. Singh’s peer-reviewed research on “Microscale bioadhesive hydrogel arrays for cell engineering applications” will be published in the journal’s Young Innovators issue and the assistant professor of mechanical and aerospace engineering has been invited to present the work at the 2014 Fall Biomedical Engineering Society Conference in San Antonio, Oct 22–25.   Read more at Cornell MAE Spotlights or Cornell Engineering News

07/2014 Alberto completes his Summer Immersion training at Weill Cornell Medical College working with Dr. Sandip Kapur in transplantation surgery! See pics here.
StartFragmentEndFragment

07/2014 Prof. Singh to give an invited talk on stem cell biomechanics at the 7th World Congress of Biomechanics - Boston, July 10 '14. 


06/2014 Prof. Singh's work selected in Nature's special collection in stem cell reprogramming!! Link

05/2014 Singh Lab awarded a $50,000 "2014 Seed Grant for Collaborations Between Cornell University-Ithaca and Weill Cornell Medical College Faculty"- collaboration involving Dr. Ari Melnick from the Weill Cornell Medical College to study blood cancer.  
                                               

05/2014 Prof. Singh receives his first R21 grant from National Institutes of Health (NIH) and National Cancer Institute (NCI) to engineer biomaterials for B and T cell Lymphomas. 

05/2014 Dr. Ye (Field) Tian joins lab as first postdoctoral fellow. Welcome Field! 

04/2014 Prof. Singh to present two talks at the 2014 Annual Society for Biomaterials Meeting in Denver, CO. 

03/2014 Ravi Patel publishes his first article in IEEE Pulse- Miniature Medicine: Nanomaterials for therapeutic delivery and cell engineering applications. Congratulations Ravi!

03/2014 Prof Singh's new paper on treating Osteoarthritis accepted for publication in Advanced Healthcare Materials. More details to follow. 

02/2014 Prof. Singh elected as the inaugural Chair of the newly founded Immune Engineering Special Interest Group at the Society for Biomaterials (SFB). SIG will have its first face-to-face meeting on Thursday, April 17 from 7:00 - 8:00 am at 2014 Annual Meeting & Exposition | April 16-19, 2014 Denver, CO. 

02/2014 Dr. Singh presents research work in two-platform session at the 2014 ASME 3rd Global Congress on Nanoengineering in Biology and Medicine (San Francisco, CA)

01/2014 Alberto Purwada publishes new article in Acta Biomaterialia - "Engineering Vaccines and Niches for Immune Modulation". Congrats AP!

01/2014 New paper on "High Fidelity Nanopatterning of Proteins onto Well-Defined Surfaces Through Subtractive Contact Printing" published in Methods in Cell Biology

01/2014 Prof. Singh selected as a recipient of the Rising Star Award for the 2014 Biomedical Engineering Society Cellular and Molecular Engineering Meeting to be held in La Jolla, CA. The theme for this scientific meeting is Multi Scale Mechanobiology - From Morphogenesis to Nuclear Mechanotransduction.

12/2013 Dr. Singh research on injectable scaffold for Lymphoma highlighted in Nature Outlook's "Cancer Vaccines: Materials Breach". 

11/2013 Congrats Daniel Leach for being awarded the HEAA research grant

10/2013 Ravi Patel (ME, PhD.) joins the lab! Welcome!

10/2013 Alberto Purwada (BME, Ph.D.), Peter Gu (MAE, M.Eng) join the lab! Welcome!

10/2013  New paper on "Microfluidic-based patterning of embryonic stem cells for in vitro development studies." published in Lab on a Chip (2013)

08/2013 Singh's collaborative work on "Single-Cell Analysis of Embryoid Body Heterogeneity Using Microfluidic Trapping Array" accepted for publication in Biomedical Microdevices. (2013)    

ACS

Discover

adhm201470051-gra-0001-m

F1

Book

CMBE-YoungInnovatorCover2014

60952_417689704970581_1148785184_n

PTO000068-2

ss