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Sibley School of Mechanical and Aerospace Engineering at Cornell University

 

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Brian J. Kirby
Assistant Professor
Mechanical and Aerospace Engineering
Research Group Web Page: Micro/Nanofluidics Laboratory
Address:    238 Upson Hall
Cornell University
Ithaca, NY 14853
Phone: 
Fax:    
E-mail:
(607) 255-4379
607) 255-1222
bk88@cornell.edu

Dr. Kirby develops miniaturized devices for biochemical analysis, and has interests in micro- and nanoscale fluid transport, laser microfabrication, biomaterials, microscale cell culture, electrochemistry, and micro- and nanoparticle manipulation. Dr. Kirby is the director of the Micro/Nanofluidics Laboratory, and more information can be obtained at the Micro/Nanofluidics Laboratory website.

Research Positions
Features
Kirby Lab microfluidics nanofluidics Fluid mechanics at the nanoscale
How nanofabrication and membrane technology create new technological applications of teeny tiny fluid physics
Kirby Lab microfluidics nanofluidics The zeta potential
How we model and predict electroosmotic phenomena in microdevices
Kirby Lab microfluidics nanofluidics Environmental sampling
Detecting viral pathogens in complex water systems
Honors and Awards
  • 2002 R&D 100 Top Invention Award
  • 2004 J.D. Watson Investigator Award
  • 2006 Presidential Early Career Award for Scientists and Engineers (PECASE) Award
  • 2008 Selected for National Academy of Engineering Frontiers of Engineering Symposium
  • 2008 Mr. & Mrs. Richard F. Tucker Excellence in Teaching Award
Courses
  • MAE 427: Fluid Mechanics and Heat Transfer Laboratory
  • MAE 423/523: Intermediate Fluid Dynamics
  • MAE 524/624: Physics of Micro- and Nanoscale Fluid Mechanics
Undergraduate Advising
Selected Publications

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics for Engineers," textbook in preparation for publication in 2009.
click here for html version| Cambridge University Press

Rouillard AD, Berglund CM, Lee JY, Polacheck WJ, Tsui YT, Bonassar LJ, Kirby BJ
"Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability," submitted, 2009.

Gleghorn JP, Pratt ED, Denning D, Liu H, Bander NH, Tagawa S, Nanus DM, Giannakakou PA, Kirby BJ
"Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture and a prostate-specific antibody", Lab on a Chip, accepted, 2009.

Rouillard AD, Tsui YT, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Control of the Electromechanical Properties of Alginate Hydrogels via Ionic and Covalent Crosslinking and Microparticle Doping," submitted, 2009.

PDF version of Brian Kirby Nanofluidics review

Kirby BJ
"Nanofluidics" (book review), Materials Today, 12(5) 51, 2009. doi pdf

PDF version of Tandon Kirby: Transient zeta potential measuremnts in hydrophobic topas microfluidics substrates

Tandon VT, Bhagavatula S, Kirby BJ
"Transient Zeta Potential Measurements in Hydrophobic, TOPAS Microfluidic Substrates," Electrophoresis 30(15) 2656-2667, 2009. doi pdf

PDF version of Refolding of beta-galactosidase: microfluidic device for reagent metering and mixing and quantification of refolding yield 
Sowmya Kondapalli and Brian J. Kirby

Kondapalli S, Kirby BJ
"Refolding of beta-galactosidase: Microfluidic device for reagent metering and mixing and quantification of refolding yield," Microfluidics and Nanofluidics 7(2) 275-281, 2009. doi pdf

Hawkins BG, Gleghorn JP, Kirby BJ
"Dielectrophoresis for cell and particle manipulation," submitted, 2008.

PDF version of George, Rana, Hawkins, Kirby: 
Microfluidic devices for terahertz spectroscopy of biomolecules

George PA, Hui W, Rana F, Hawkins BG, Smith AE, Kirby BJ
"Integrated microfluidic devices for terahertz spectroscopy of biomolecules", Optics Express, 16(3) 1577-1582 (2008). pdf text

PDF version of Tandon V Bhagavatula SK Nelson WC Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge

Tandon V, Bhagavatula SK, Nelson WC, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge", Electrophoresis 29(5):1092-1101, 2008. doi pdf

PDF version of Tandon V Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices 
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure

Tandon V, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 2. Slip and interfacial water structure", Electrophoresis 29(5):1102-1114, 2008. doi pdf

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

PDF version of Ghosh, Bhagwat, Renshaw, Goh, Gaeta, Kirby: Low-light-level optical interactions with rubidium vapor in a photonic band-gap fiber

Ghosh S, Bhagwat AR, Renshaw CK, Goh S, Gaeta AL, Kirby BJ
"Low-light-level optical interactions with rubidium vapor in a photonic band-gap fiber," Physical Review Letters 97:023603 (2006). doi pdf arxiv

Wilkes JO , with Birmingham SG, Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD," Prentice-Hall, 2005.
click here to go to text webpage

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 1. Theory, experimental techniques, and effects on separations

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 1. Theory, experimental techniques, and effects on separations," Electrophoresis, 25:187-202 (2004). doi pdf text

PDF version of Reichmuth, Chirica, Kirby: Increasing the performance of high-pressure, high-efficiency electrokinetic micropumps using zwitterionic solute additives

Reichmuth DS, Chirica GS, Kirby BJ
"Increasing the Performance of High-Pressure, High-Efficiency Electrokinetic Micropumps Using Zwitterionic Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003). doi pdf text

Brian Kirby joined the Cornell MAE faculty in 2004. Previous to that, he was a research scientist at Sandia National Laboratories and Stanford University. See more at the Micro/Nanofluidics Laboratory website.

Education
Ph.D. 2001  -  Stanford University, Mechanical Engineering
M.S.E. 1996  -  University of Michigan, Mechanical Engineering
B.S.E. 1994  -  University of Michigan, Aerospace Engineering